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Modalert -- precisely what are we buying really - longecity
I have to bring this old post from another website to discuss. It's also mentioned here as a vintage THREAD link.



Posted: November 05 2006 Post subject: Provigil (modafinil): Why It Fails & Info



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Good afternoon. We are visiting this forum to present some insights about Provigil (modafinil). You can be assured that I am not related to Cephalon, which will be obvious from my comments concerning the drug. However, I've done a substantial amount of research in the various studies on the drug.



Executive Summary:



When Provigil fights for you personally, try taking 1-3 slow days through the drug.



Alternatively, try lowering your dosage to 75% of what you found originally effective.



Taking more Provigil doesn't usually solve the problem in the long run.



Don't take over 600 mg/day. If you're taking over 400 mg/day, monitor your blood pressure level.





Outline:

1. Modafinil normally

2. Some Precautions

3. Theory: Why Modafinil Fails



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1. MODAFINIL On the whole



My top priority the following is accessibility, not completeness and precision. If you wish to learn the more version from the story, I would recommend doing all of your own research.



Adrafinil, a. k. a. Olmifon, was discovered from the 1970s. Adrafinil is uncontrolled. You don't need a prescription for doing this. It's also unpatented. You can find it for affordable.



Adrafinil in time breaks down into Modafinil (and several various other pieces). That other stuff causes unwanted effects in a few people: stomach aches and skin irritation. The use of it for several months, you have to have your liver enzymes checked; it may well alter how we metabolize other drugs. Any alteration of liver enzymes disappears when you finally stop taking it, though.



Modafinil breaks down into l-modafinil and d-modafinil (and some other things). Both l-modafinil and d-modafinil have stimulant effects. Both reach their peak levels after 1. 5 to two. 5 hours (for most people). L-modafinil lasts for a longer time than D-modafinil; it features a 12-ish hour half-life. D-modafinil's half-life is 3-ish hours.



L-modafinil, a. k. a. R-modafinil, a. k. a. Armodafinil, a. k. a. Nuvigil will probably become so popular-so fast early 2007, supposedly. When isolated, Cephalon claims that l-modafinil needs a little longer to peak (5-6 hours). This "smoothes out" manufactured.



400 mg adrafinil ~= 200 mg modafinil ~= 100 mg armodafinil.



Adrafinil is super cheap because it's unpatented and doesn't demand a prescription in the usa.



Modafinil is super expensive (~$8. 50/200mg) until 2011 if this becomes slightly cheaper (as the result of some complicated lawsuit settlements with generic manufacturers) until 2014 gets hotter becomes completely generic.



Armodafinil will likely be super expensive likewise.



NOTE: Modafinil is available from overseas manufactures as Modalert, Modatec, and lots of other brands for about $1. 50 (US patents don't apply in India). Take care because (a) it really is technically illegal to import these, but a 90-day personal supply is usually forgiven by customs, and (b) these products are legitimate, but a majority of overseas pharmacies sell counterfeit versions. Perform large amount of research. I can't allow you to here, for legal reasons.





2. SOME PRECAUTIONS



As I'm sure the majority of you know, the FDA-approved dosage is 200 mg for narcolepsy. Cephalon's (publicly) recommended dose can be a maximum of 400 mg. Whatever.



Take warning in exceeding 600 mg each day. Cephalon's Phase 1 trials tested out 600 mg/day and 800 mg/day and found that 800 mg/day was unsafe as a result of blood pressure levels and pulse rate changes.



Should you refer to taking 600 mg/day or higher, look at your hypertension and heartbeat often. You can find an automated blood pressure and pulse monitor from Omron for $55 from Amazon.



If your high blood pressure is 140/90 to 180/120 (either number within that range), see a doctor about getting medicine for high blood pressure level. Or decrease your dosage. Should your high blood pressure is between 180/120 and 220/140, seek immediate attention. When your blood pressure ends 220/140, visit the hospital.





3. THEORY: WHY MODAFINIL STOPS WORKING



Firstly, Cephalon can never admit that this happens. In reality, they've funded several studies to prove that folks don't produce a tolerance to modafinil. But read some anecdotes online; something is wrong.



The majority of people find modafinil effective for the first day (given 200 mg/day). Extremely effective. There after, it's iffy. For many people, it in time breaks down by the third day. For others, it in time breaks down after 21 days. For some individuals still, it stops working after A few months. With the lucky few, it functions for over 2 years.



I've got two theories as to the reasons that might be.



THEORY A: Modafinil becomes ineffective when you have an excessive amount it in your soul.



Modafinil has a long half-life. A day after you grab the first dose, you still have some amount of the drug left in you. Whenever you go on it every day, the modafinil levels persist in increasing.



After 4-7 days, you reach a "steady state" level. This level approximately 30% higher than a single dose, dependant upon individual factors. Thus, taking 400 mg for any week is a lot like taking 520 mg the very first time.



If this is true, then raising the dose would be the wrong solution. But that's what individuals look like doing. 200 mg stops working for him or her after a week, so they really check out 400, then 600, then get frustrated and quit.



If the theory is correct, then:



(a) Raising your everyday dose should never relieve your symptoms much more.

(b) After the 1-3 day "drug holiday" off modafinil (taking no modafinil whatsoever), it must are well as being the first time after you make same dose as the first-time [200mg].

Reducing the daily dose by 25% should relieve symptoms. One example is, if 200 mg was effective around the first day, then taking 150 mg every day for any week should make contact with that level. (150 * 130% = 200; plasma levels are dose-proportional)







THEORY B: Modafinil affects your sleep architecture.



It was briefly mentioned within a few studies that I've read, however haven't considered this complete.



The thought is that, once you take modafinil daily, your "trough levels" (the extent inside you each day before it) get high enough so it affects your sleep. In case your sleep decreases restful, this would make you more tired the very next day.



If this theory is correct, then:



(a) Raising your dose ought not relieve your symptoms any more. (Actually, it would cause them to worse on the next few days. )

(b) A 1-3 day drug holiday, with plenty of rest, should make modafinil start working again whenever you resume.

Lowering your daily dose may well not help.







Just as one off-topic comment: Modafinil can are amiss for everyone, not simply people who have insomnia.



DISCLAIMER: I'm not really a physician. This may not be medical health advice. I wouldn't recommend by using this information with the basis of any decision. Talk to your doctor prior to making any medical decision buy amoxicillin online.



If any one you decide to do this stuff (under supervision, of course. . . ), reply and indicate the way it goes.
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